ScRNAseq

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma featured image

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma

BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare lymphoma of the central nervous system, usually of diffuse large B cell phenotype. Stereotactic biopsy …

michael-heming
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia featured image

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

We deeply characterize tissue-resident leukocytes in meninges and brain parenchyma and discover that leukocytes respond differently to stroke depending on their site of residence. …

carolin-beuker
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges. featured image

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.

Based on single-cell transcriptomics, we here identify a highly location-specific composition and expression profile of tissue-resident leukocytes in CNS border compartments …

david-schafflick
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid featured image

Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

We utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid of Neuro-COVID patients and discovered an expansion of dedifferentiated …

michael-heming

Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity.

Peripheral nerves contain axons and their enwrapping glia cells named Schwann cells (SCs) that are either myelinating (mySCs) or nonmyelinating (nmSCs). Our understanding of other …

jolien-wolbert

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

david-schafflick