Compartments

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia featured image

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

We deeply characterize tissue-resident leukocytes in meninges and brain parenchyma and discover that leukocytes respond differently to stroke depending on their site of residence. …

carolin-beuker
Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation. featured image

Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation.

By generating a compartment-specific transcriptional map of meningeal versus parenchymal leukocytes in experimental neuroinflammation, we found a follicular phenotype of meningeal …

maike-hartlehnert
Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses featured image

Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses

We performed basic CSF analysis and multi-dimensional flow cytometry of CSF and blood cells from 59 patients with primary psychotic disorders in comparison to inflammatory and …

saskia-rauber
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges. featured image

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.

Based on single-cell transcriptomics, we here identify a highly location-specific composition and expression profile of tissue-resident leukocytes in CNS border compartments …

david-schafflick

Leukocyte profiles in blood and CSF distinguish neurosarcoidosis from multiple sclerosis

Distinguishing neurosarcoidosis (NS) from multiple sclerosis (MS) remains challenging and available parameters lack discriminatory power. Comprehensive flow cytometry data of blood …

michael-heming

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

david-schafflick